as of September, 2021:
| County | Employment | Unemployment | Unemployment Rate | Labor Force |
|---|---|---|---|---|
| Adair | 9,517 | 245 | 2.5 | 9,762 |
| Andrew | 9,534 | 170 | 1.8 | 9,704 |
| Atchison | 2,514 | 53 | 2.1 | 2,567 |
| Audrain | 9,804 | 231 | 2.3 | 10,035 |
| Barry | 14,614 | 395 | 2.6 | 15,009 |
| Barton | 5,034 | 107 | 2.1 | 5,141 |
| Bates | 7,518 | 190 | 2.5 | 7,708 |
| Benton | 6,945 | 233 | 3.2 | 7,178 |
| Bollinger | 5,194 | 134 | 2.5 | 5,328 |
| Boone | 96,919 | 1,793 | 1.8 | 98,712 |
| Buchanan | 42,710 | 1,022 | 2.3 | 43,732 |
| Butler | 17,215 | 496 | 2.8 | 17,711 |
| Caldwell | 4,186 | 186 | 4.3 | 4,372 |
| Callaway | 21,214 | 441 | 2.0 | 21,655 |
| Camden | 18,481 | 521 | 2.7 | 19,002 |
| Cape Girardeau | 39,351 | 879 | 2.2 | 40,230 |
| Carroll | 4,288 | 133 | 3.0 | 4,421 |
| Carter | 2,501 | 73 | 2.8 | 2,574 |
| Cass | 53,834 | 1,342 | 2.4 | 55,176 |
| Cedar | 5,686 | 134 | 2.3 | 5,820 |
| Chariton | 3,585 | 66 | 1.8 | 3,651 |
| Christian | 44,936 | 875 | 1.9 | 45,811 |
| Clark | 2,967 | 86 | 2.8 | 3,053 |
| Clay | 135,196 | 5,770 | 4.1 | 140,966 |
| Clinton | 10,398 | 473 | 4.4 | 10,871 |
| Cole | 39,006 | 732 | 1.8 | 39,738 |
| Cooper | 6,952 | 156 | 2.2 | 7,108 |
| Crawford | 10,538 | 288 | 2.7 | 10,826 |
| Dade | 3,504 | 68 | 1.9 | 3,572 |
| Dallas | 6,843 | 184 | 2.6 | 7,027 |
| Daviess | 4,031 | 108 | 2.6 | 4,139 |
| DeKalb | 4,644 | 120 | 2.5 | 4,764 |
| Dent | 6,108 | 172 | 2.7 | 6,280 |
| Douglas | 4,915 | 122 | 2.4 | 5,037 |
| Dunklin | 10,621 | 408 | 3.7 | 11,029 |
| Franklin | 50,633 | 1,275 | 2.5 | 51,908 |
| Gasconade | 7,354 | 185 | 2.5 | 7,539 |
| Gentry | 3,222 | 55 | 1.7 | 3,277 |
| Greene | 149,341 | 3,126 | 2.1 | 152,467 |
| Grundy | 4,057 | 92 | 2.2 | 4,149 |
| Harrison | 3,572 | 75 | 2.1 | 3,647 |
| Henry | 9,695 | 219 | 2.2 | 9,914 |
| Hickory | 3,837 | 92 | 2.3 | 3,929 |
| Holt | 2,422 | 39 | 1.6 | 2,461 |
| Howard | 4,705 | 94 | 2.0 | 4,799 |
| Howell | 15,234 | 465 | 3.0 | 15,699 |
| Iron | 3,297 | 121 | 3.5 | 3,418 |
| Jackson | 352,810 | 13,668 | 3.7 | 366,478 |
| Jasper | 54,926 | 1,286 | 2.3 | 56,212 |
| Jefferson | 112,611 | 2,864 | 2.5 | 115,475 |
| Johnson | 22,276 | 569 | 2.5 | 22,845 |
| Knox | 1,667 | 27 | 1.6 | 1,694 |
| Laclede | 15,816 | 414 | 2.6 | 16,230 |
| Lafayette | 16,416 | 500 | 3.0 | 16,916 |
| Lawrence | 16,888 | 377 | 2.2 | 17,265 |
| Lewis | 4,643 | 95 | 2.0 | 4,738 |
| Lincoln | 27,567 | 1,124 | 3.9 | 28,691 |
| Linn | 4,792 | 144 | 2.9 | 4,936 |
| Livingston | 7,069 | 146 | 2.0 | 7,215 |
| Macon | 7,093 | 154 | 2.1 | 7,247 |
| Madison | 5,200 | 150 | 2.8 | 5,350 |
| Maries | 3,757 | 97 | 2.5 | 3,854 |
| Marion | 13,841 | 297 | 2.1 | 14,138 |
| McDonald | 10,679 | 246 | 2.3 | 10,925 |
| Mercer | 1,785 | 29 | 1.6 | 1,814 |
| Miller | 12,328 | 281 | 2.2 | 12,609 |
| Mississippi | 5,218 | 156 | 2.9 | 5,374 |
| Moniteau | 7,249 | 137 | 1.9 | 7,386 |
| Monroe | 3,621 | 96 | 2.6 | 3,717 |
| Montgomery | 5,510 | 169 | 3.0 | 5,679 |
| Morgan | 8,054 | 223 | 2.7 | 8,277 |
| New Madrid | 7,995 | 249 | 3.0 | 8,244 |
| Newton | 26,006 | 608 | 2.3 | 26,614 |
| Nodaway | 10,307 | 185 | 1.8 | 10,492 |
| Oregon | 3,688 | 116 | 3.0 | 3,804 |
| Osage | 7,031 | 107 | 1.5 | 7,138 |
| Ozark | 3,322 | 112 | 3.3 | 3,434 |
| Pemiscot | 5,768 | 267 | 4.4 | 6,035 |
| Perry | 9,399 | 185 | 1.9 | 9,584 |
| Pettis | 18,837 | 481 | 2.5 | 19,318 |
| Phelps | 19,265 | 444 | 2.3 | 19,709 |
| Pike | 7,107 | 189 | 2.6 | 7,296 |
| Platte | 58,277 | 1,672 | 2.8 | 59,949 |
| Polk | 14,118 | 299 | 2.1 | 14,417 |
| Pulaski | 13,660 | 388 | 2.8 | 14,048 |
| Putnam | 2,100 | 35 | 1.6 | 2,135 |
| Ralls | 5,442 | 108 | 1.9 | 5,550 |
| Randolph | 9,778 | 265 | 2.6 | 10,043 |
| Ray | 10,730 | 716 | 6.3 | 11,446 |
| Reynolds | 2,898 | 83 | 2.8 | 2,981 |
| Ripley | 4,785 | 172 | 3.5 | 4,957 |
| Saline | 10,210 | 213 | 2.0 | 10,423 |
| Schuyler | 1,808 | 45 | 2.4 | 1,853 |
| Scotland | 2,261 | 36 | 1.6 | 2,297 |
| Scott | 19,509 | 471 | 2.4 | 19,980 |
| Shannon | 3,214 | 103 | 3.1 | 3,317 |
| Shelby | 2,869 | 48 | 1.6 | 2,917 |
| St. Charles | 218,515 | 5,641 | 2.5 | 224,156 |
| St. Clair | 3,622 | 101 | 2.7 | 3,723 |
| St. Francois | 24,627 | 742 | 2.9 | 25,369 |
| St. Louis | 505,174 | 15,362 | 3.0 | 520,536 |
| St. Louis city | 143,153 | 6,151 | 4.1 | 149,304 |
| Ste. Genevieve | 8,989 | 185 | 2.0 | 9,174 |
| Stoddard | 12,575 | 343 | 2.7 | 12,918 |
| Stone | 12,059 | 459 | 3.7 | 12,518 |
| Sullivan | 2,573 | 77 | 2.9 | 2,650 |
| Taney | 23,372 | 1,022 | 4.2 | 24,394 |
| Texas | 8,741 | 258 | 2.9 | 8,999 |
| Vernon | 9,041 | 206 | 2.2 | 9,247 |
| Warren | 17,559 | 594 | 3.3 | 18,153 |
| Washington | 9,570 | 305 | 3.1 | 9,875 |
| Wayne | 4,540 | 144 | 3.1 | 4,684 |
| Webster | 16,994 | 375 | 2.2 | 17,369 |
| Worth | 1,116 | 19 | 1.7 | 1,135 |
| Wright | 7,315 | 182 | 2.4 | 7,497 |