as of September, 2021:
| County | Employment | Unemployment | Unemployment Rate | Labor Force |
|---|---|---|---|---|
| Abbeville | 9,321 | 377 | 3.9 | 9,698 |
| Aiken | 72,552 | 2,002 | 2.7 | 74,554 |
| Allendale | 2,267 | 161 | 6.6 | 2,428 |
| Anderson | 88,717 | 2,608 | 2.9 | 91,325 |
| Bamberg | 4,174 | 302 | 6.7 | 4,476 |
| Barnwell | 7,142 | 424 | 5.6 | 7,566 |
| Beaufort | 76,995 | 2,072 | 2.6 | 79,067 |
| Berkeley | 102,752 | 3,087 | 2.9 | 105,839 |
| Calhoun | 6,322 | 266 | 4.0 | 6,588 |
| Charleston | 206,331 | 6,082 | 2.9 | 212,413 |
| Cherokee | 23,805 | 1,024 | 4.1 | 24,829 |
| Chester | 12,830 | 683 | 5.1 | 13,513 |
| Chesterfield | 20,632 | 874 | 4.1 | 21,506 |
| Clarendon | 12,128 | 498 | 3.9 | 12,626 |
| Colleton | 15,647 | 557 | 3.4 | 16,204 |
| Darlington | 29,085 | 1,124 | 3.7 | 30,209 |
| Dillon | 12,662 | 682 | 5.1 | 13,344 |
| Dorchester | 75,917 | 2,286 | 2.9 | 78,203 |
| Edgefield | 10,344 | 274 | 2.6 | 10,618 |
| Fairfield | 9,095 | 473 | 4.9 | 9,568 |
| Florence | 64,895 | 2,223 | 3.3 | 67,118 |
| Georgetown | 24,562 | 1,006 | 3.9 | 25,568 |
| Greenville | 250,596 | 7,139 | 2.8 | 257,735 |
| Greenwood | 29,087 | 1,161 | 3.8 | 30,248 |
| Hampton | 7,950 | 237 | 2.9 | 8,187 |
| Horry | 143,232 | 5,925 | 4.0 | 149,157 |
| Jasper | 12,863 | 331 | 2.5 | 13,194 |
| Kershaw | 28,615 | 901 | 3.1 | 29,516 |
| Lancaster | 40,971 | 1,644 | 3.9 | 42,615 |
| Laurens | 29,177 | 1,042 | 3.4 | 30,219 |
| Lee | 6,353 | 322 | 4.8 | 6,675 |
| Lexington | 147,662 | 3,729 | 2.5 | 151,391 |
| Marion | 12,493 | 749 | 5.7 | 13,242 |
| Marlboro | 8,421 | 648 | 7.1 | 9,069 |
| McCormick | 3,118 | 133 | 4.1 | 3,251 |
| Newberry | 18,935 | 504 | 2.6 | 19,439 |
| Oconee | 33,272 | 978 | 2.9 | 34,250 |
| Orangeburg | 30,849 | 2,198 | 6.7 | 33,047 |
| Pickens | 56,186 | 1,571 | 2.7 | 57,757 |
| Richland | 193,089 | 6,711 | 3.4 | 199,800 |
| Saluda | 8,436 | 203 | 2.3 | 8,639 |
| Spartanburg | 155,310 | 5,068 | 3.2 | 160,378 |
| Sumter | 41,543 | 1,643 | 3.8 | 43,186 |
| Union | 11,454 | 653 | 5.4 | 12,107 |
| Williamsburg | 10,557 | 578 | 5.2 | 11,135 |
| York | 139,984 | 4,644 | 3.2 | 144,628 |