as of September, 2021:
| County | Employment | Unemployment | Unemployment Rate | Labor Force |
|---|---|---|---|---|
| Aurora | 1,454 | 27 | 1.8 | 1,481 |
| Beadle | 8,986 | 198 | 2.2 | 9,184 |
| Bennett | 1,013 | 32 | 3.1 | 1,045 |
| Bon Homme | 2,757 | 61 | 2.2 | 2,818 |
| Brookings | 17,808 | 395 | 2.2 | 18,203 |
| Brown | 20,081 | 467 | 2.3 | 20,548 |
| Brule | 2,485 | 51 | 2.0 | 2,536 |
| Buffalo | 670 | 20 | 2.9 | 690 |
| Butte | 4,912 | 123 | 2.4 | 5,035 |
| Campbell | 783 | 21 | 2.6 | 804 |
| Charles Mix | 3,652 | 98 | 2.6 | 3,750 |
| Clark | 1,936 | 46 | 2.3 | 1,982 |
| Clay | 7,098 | 147 | 2.0 | 7,245 |
| Codington | 15,122 | 334 | 2.2 | 15,456 |
| Corson | 1,284 | 47 | 3.5 | 1,331 |
| Custer | 4,068 | 116 | 2.8 | 4,184 |
| Davison | 10,741 | 219 | 2.0 | 10,960 |
| Day | 2,632 | 70 | 2.6 | 2,702 |
| Deuel | 2,335 | 64 | 2.7 | 2,399 |
| Dewey | 2,268 | 103 | 4.3 | 2,371 |
| Douglas | 1,515 | 29 | 1.9 | 1,544 |
| Edmunds | 1,977 | 41 | 2.0 | 2,018 |
| Fall River | 3,008 | 82 | 2.7 | 3,090 |
| Faulk | 1,007 | 24 | 2.3 | 1,031 |
| Grant | 4,290 | 85 | 1.9 | 4,375 |
| Gregory | 2,020 | 42 | 2.0 | 2,062 |
| Haakon | 1,019 | 22 | 2.1 | 1,041 |
| Hamlin | 3,435 | 55 | 1.6 | 3,490 |
| Hand | 1,720 | 35 | 2.0 | 1,755 |
| Hanson | 1,694 | 40 | 2.3 | 1,734 |
| Harding | 697 | 16 | 2.2 | 713 |
| Hughes | 9,940 | 172 | 1.7 | 10,112 |
| Hutchinson | 3,495 | 75 | 2.1 | 3,570 |
| Hyde | 634 | 15 | 2.3 | 649 |
| Jackson | 1,242 | 37 | 2.9 | 1,279 |
| Jerauld | 1,337 | 25 | 1.8 | 1,362 |
| Jones | 508 | 14 | 2.7 | 522 |
| Kingsbury | 2,674 | 59 | 2.2 | 2,733 |
| Lake | 6,381 | 141 | 2.2 | 6,522 |
| Lawrence | 13,777 | 304 | 2.2 | 14,081 |
| Lincoln | 35,909 | 638 | 1.7 | 36,547 |
| Lyman | 1,598 | 52 | 3.2 | 1,650 |
| Marshall | 2,389 | 56 | 2.3 | 2,445 |
| McCook | 3,088 | 57 | 1.8 | 3,145 |
| McPherson | 934 | 26 | 2.7 | 960 |
| Meade | 14,082 | 318 | 2.2 | 14,400 |
| Mellette | 691 | 21 | 2.9 | 712 |
| Miner | 1,100 | 25 | 2.2 | 1,125 |
| Minnehaha | 112,712 | 2,197 | 1.9 | 114,909 |
| Moody | 3,979 | 80 | 2.0 | 4,059 |
| Oglala Lakota | 3,530 | 252 | 6.7 | 3,782 |
| Pennington | 57,491 | 1,320 | 2.2 | 58,811 |
| Perkins | 1,359 | 32 | 2.3 | 1,391 |
| Potter | 1,016 | 24 | 2.3 | 1,040 |
| Roberts | 4,679 | 131 | 2.7 | 4,810 |
| Sanborn | 1,162 | 27 | 2.3 | 1,189 |
| Spink | 2,942 | 71 | 2.4 | 3,013 |
| Stanley | 1,881 | 39 | 2.0 | 1,920 |
| Sully | 792 | 17 | 2.1 | 809 |
| Todd | 2,826 | 98 | 3.4 | 2,924 |
| Tripp | 2,951 | 51 | 1.7 | 3,002 |
| Turner | 4,674 | 81 | 1.7 | 4,755 |
| Union | 8,207 | 211 | 2.5 | 8,418 |
| Walworth | 2,091 | 70 | 3.2 | 2,161 |
| Yankton | 11,230 | 223 | 1.9 | 11,453 |
| Ziebach | 975 | 30 | 3.0 | 1,005 |